NAD+ precursor response is personal.
The enzymes that rebuild your NAD⁺ stores vary by individual and tissue type, so the same supplement may not work equally for everyone.
Supporting multiple pathways with NMN, NR, and Trigonelline provides consistent, reliable NAD⁺ support—without the guesswork.
Liposomal delivery provides enhanced bioavailability.
Liposomal delivery encapsulates sensitive ingredients like NMN and NR in phospholipids—the same fats that make up cell membranes—protecting them during digestion and first-pass liver metabolism. This allows more of the active ingredients to reach your cells where they’re needed most, resulting in stronger effects at significantly lower doses.
Live better, longer.
The most scientifically advanced formulas designed to restore yourNAD+levels and optimize your potential for healthy longevity.
Which NAD+ Precursor Is Best?
NAD+
This central coenzyme is directly involved in redox reactions and acts as a substrate for enzymes involved in energy production, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.
NMN
This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown in numerous clinical trials to effectively increase intracellular NAD+ levels, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.
NR
This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also been shown to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in the DNA damage response and oxidative stress mitigation. By boosting NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulate cellular metabolism.
Trigonelline
Trigonelline promotes cellular NAD+ production differently from NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing effects, protection from stomach digestion, and a direct increase of NAD+ in muscle tissues.
Our Team
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Bryan Nettles
Founder and CEO
Nutrition and exercise have been primary focuses for me throughout my life. My passion lies in science and research, particularly as it relates to healthy aging. -
Dr. Rebecca Crews
Research Director
Dr. Rebecca Crews is the Research Director at Renue by Science, where she leads the company’s efforts in transformative research. -
Dr. Clark Driggers
Chief Medical Advisor
Dr. Clark Driggers serves as the Chief Medical Advisor at Renue by Science, specializing in wellness, anti-aging, and regenerative medicine.
Unlock Your Potential with PURE NMN
PURE NMN is a high-purity supplement that naturally boosts NAD+ levels. It supports cellular energy, DNA repair, and metabolic health, helping you feel energized, focused, and resilient. With rapid absorption and science-backed benefits, PURE NMN is your key to thriving and staying vibrant every day.
What our customers have to say
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★★★★★
Great product! It helps me sleep, and I have noticed a significant improvement in my eyesight since I began taking it a year ago.
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★★★★★
I’ve been taking NMN powder for several years and have not experienced any health issues. I believe it is supporting my system, as my test results have been consistently good.
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★★★★★
I like to use it for at least 30 days before sharing my thoughts, but so far it has made me feel a lot better.
FAQS
Where are your products manufactured?
Where are your products manufactured?
All Renue by Science products are manufactured in cGMP-certified facilities in the United States. We partner with manufacturers who exceed standard GMP requirements to ensure the highest quality production. They maintain strict quality controls throughout the entire process, from raw material sourcing to final bottling.
What quality standards do your products meet?
What quality standards do your products meet?
Quality and safety are our top priorities. Our products are manufactured in cGMP-certified facilities that exceed industry standards. This certification ensures the most current and rigorous quality controls. Every batch undergoes third-party testing to verify purity, potency, and compliance with label claims.
Where do you source your NMN from?
Where do you source your NMN from?
Our raw NMN is sourced from select suppliers in China, which is common practice in the vitamin and supplement industry. While we have previously worked with multiple vendors, we now source exclusively from Effepharm due to their consistent reliability and quality. That said, we maintain relationships with other suppliers to ensure an uninterrupted NMN supply when needed.
How do you ensure product quality?
How do you ensure product quality?
Safety and purity are our top priorities, and we have implemented rigorous testing procedures that exceed industry standards. Our process includes: 1) initial testing of raw ingredients upon receipt in the United States; 2) processing and refinement in FDA-registered facilities; and 3) comprehensive testing of each batch of finished product. We are committed to full transparency in our quality control process. We are the only brand in the industry to publish detailed test results for every batch of finished product on our website. Each product is labeled with a batch number, allowing customers to verify the test results for their purchase.